Research Paper Volume 15, Issue 2 pp 542—552

Figure 1. Metformin reduced body weight and alleviated glucose and lipid metabolism disorders in ob/ob mice. C57BL/6 and ob/ob mice were treated with 200 mg/kg metformin for 16 weeks. Body weight (A) and random blood glucose (B) were presented every 2 weeks. The level of serum TG/TC/LDL-C and insulin were exhibited in (C and F) respectively. (D, E) The curve and area under the curve (AUC) of ITT in each group. Liver sections were prepared from C57BL/6 and ob/ob mice, HE (G–J), and evaluation of hepatic steatosis (K), ballooning (L) and inflammation (M) was carried out. Scale bar = 200 μm. Data are presented as mean ± S.E.M. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. ob ctr.