Research Paper Volume 15, Issue 2 pp 441—458
Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity
Figure 5. Senolysis in an acute insulin resistance model, S961, did not affect beta-cell proliferative capacity. (A) Area under the curve of blood glucose levels throughout the treatment period, ncontrol = 8, nS961 = 3, nS961+BB = 5. (B) Fed plasma insulin (ng/mL) levels in control, S961, and S961 + BB; significance calculated by repeated unpaired t-test. (C) qPCR of islets from S961 treated animals increased Caspase 8 transcription consistent with accelerated senescence. (D) Proliferation of beta cells (%) in 8–19-month-old mice. (E) Beta cell mass (mg) 18–19 month-old INK ATTAC mice, male and female. Mean +/− SEM, significance calculated by ordinary one-way ANOVA with Tukey’s multiple comparisons.