Figure 2. Study design to assess the effects of lithium on longevity in the UK Biobank. (A) Flowchart for inclusion and exclusion criteria in the UK Biobank cohort. Diagnoses and prescriptions were retrieved from GP clinical records and primary care datasets in National Health Service (NHS) records. One lithium user was matched to two other anti-psychotic drug users with propensity score matching using a nearest neighbor distance algorithm and the parameters indicated. (B) Most frequent ICD10 F3X diagnoses in the matched cohort of lithium and other anti-psychotic drug users.