Research Paper Volume 14, Issue 24 pp 10171—10216

The tumor microenvironment in gastrointestinal adenocarcinomas revealed a prognostic and immunotherapeutic biomarker

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Figure 5. TMEscore was an independent factor for predicting patient survival. (A) The identification flowchart of six prognostic genes (C6orf223, EPHX4, HES6, NKD2 OLR1 and ONECUT2). (B) The expression of the six genes in GIAC tumor and normal samples from TCGA cohort. (C) The RNA expression of the six genes in 55 pairs of CRC tumor and normal samples from our center (GAD and ESAD see in Supplementary Figures 7, 8). (D) The expression of the five proteins in 10 pairs of CRC tumor and normal samples from our center (GAD and ESAD see in Supplementary Figures 9, 10). (E) The WB image of protein expression for CRC (GAD and ESAD see in Supplementary Figures 11, 12). (FK) The survival time (OS and PFS) of patients with high/low TMEscore in TCGA cohort (F, G), GSE17536 (H, I) and GSE39582 (J, K).