Research Paper Volume 14, Issue 24 pp 9832—9859

Figure 6. Hypothesis: some circRNAs mobilize within the motor neuron to the NMJ/muscle during the progression of ALS. For a handful of human circRNAs identified in this study, namely hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0007778, hsa_circ_0000099, and hsa_circ_0005171, we documented an increase in ALS muscle and a concomitant decline in ALS CNS tissue. One possibility is that this shift represents a disease-associated mobilization of some circRNAs within motor neurons to the peripheral neuromuscular system (e.g., terminal motor neuron, NMJ, or endomysial space).