Figure 3.Expression patterns in ALS CNS of circRNAs previously validated as altered in ALS skeletal muscle. (A) Differential expression of a subset of circRNAs and linear counterparts in human spinal cord (cervical, thoracic, lumbar regions; n = 5 for each region in both normal and ALS samples) and frontal cortex (n = 4 normal and n = 5 ALS), that had been validated as being upregulated in ALS skeletal muscle in Figure 2A. (B) Differential expression of a subset of circRNAs and linear counterparts in human spinal cord (cervical, thoracic, lumbar regions; n = 5 for each region in both normal and ALS samples) and frontal cortex (n = 4 normal and n = 5 ALS), that had been validated as being downregulated in ALS skeletal muscle in Figure 2C. Data were normalized to RPS9 mRNA levels; p-values *p < 0.05, **p < 0.01, ***p < 0.001.
