Figure 3. Expression patterns in ALS CNS of circRNAs previously validated as altered in ALS skeletal muscle. (A) Differential expression of a subset of circRNAs and linear counterparts in human spinal cord (cervical, thoracic, lumbar regions; n = 5 for each region in both normal and ALS samples) and frontal cortex (n = 4 normal and n = 5 ALS), that had been validated as being upregulated in ALS skeletal muscle in