Research Paper Volume 14, Issue 24 pp 9832—9859

Figure 2. Differentially abundant circRNAs in ALS skeletal muscle. (A) Levels of significantly elevated circRNAs and their linear counterparts in normal (n = 12) and ALS (n = 8) muscle biopsies, as assessed by RT-qPCR analysis. (B) Levels of expression of the circRNAs and linear counterparts validated in the ALS cohort (A), as measured in normal (n = 8), myopathy (n = 8), and neuropathy (n = 5) muscle samples by RT-qPCR analysis. (C) Levels of significantly reduced circRNAs and linear counterparts in normal (n = 12) and ALS (n = 8) muscle biopsies, as assessed by RT-qPCR analysis. (D) Levels of expression of the circRNAs and linear counterparts validated in the ALS cohort (C), as measured in normal (n = 8), myopathy (n = 8), and neuropathy (n = 5) samples by RT-qPCR analysis. Data were normalized to RPS9 mRNA levels, whereas TBP mRNA levels were included as controls; p-values ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.