Research Paper Volume 14, Issue 23 pp 9393—9422

Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence

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Figure 6. Reorganization of muscle fibers with age revealed by spatial transcriptomics. (A) Young muscle fibers, several ROls are shown in yellow delineating individual sections of distinct fibers. Desmin (blue), Syto83 (green), aSMA (yellow), CD68 (red). (B) Differentially expressed genes in old versus young spatial profiled muscle. (C) log (counts) of top differentially expressed genes.