Research Paper Volume 14, Issue 23 pp 9679—9698
SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma
Figure 1. High SKA1 expression positively correlates with human renal cancer progression. (A–C), Analysis of SKA1 mRNA expression in ccRCC samples from TCGA-KIRC. (A) Analysis on SKA1 mRNA levels among ccRCC tissues, paired normal tissues, and metastatic tumor tissues (N = 72). (B) Analysis on SKA1 mRNA levels in low Fuhrman grade (G1+G2) and advanced-grade (G3+G4). (C) Kaplan–Meier analysis of ccRCC patient survival. (D) Analysis on SKA1 mRNA levels among ccRCC tissues, paired normal tissues, and metastatic tumor tissues (N = 83). (E) Representative images of IHC staining (magnification, ×100) for SKA1 protein from 83 ccRCC specimens.