Research Paper Volume 15, Issue 8 pp 2877—2890

Figure 4. Decreasing LINC01296 contributed to suppress tumorigenesis in vivo. (A) Representative images of the xenograft tumors in subcutaneous xenograft mouse model injected with M21 cells transfected with sh-NC and sh-LINC01296. (B) Tumor volume of the xenograft in each group. (C) Tumor weight of the xenograft in each group. (D) The relative expression level of LINC01296 determined by qRT-PCR analysis following transfecting with sh-NC and sh-LINC01296. (E) The tumor sections from different transfected groups of xenograft mouse models were subjected to immunohistochemistry staining using antibodies against MAPK1 (400×). (F) The tumor sections from different transfected groups of xenograft mouse models were subjected to immunohistochemistry staining using antibodies against ki-67 (400×) All of data were analyzed from three independent experiments. * P < 0.05; ** P < 0.01.