Research Paper
Adipocyte-derived exosomal miR-30c-5p promotes ovarian angiogenesis in polycystic ovary syndrome via the SOCS3/STAT3/VEGFA pathway
Figure 6. miR-30c-5p mediates the effects of adipocyte-derived exosomes on the biological function of HOMECs and the SOCS3/STAT3/VEGFA pathway. (A) qRT-PCR detection of the effect of exosomes combined with or without miR-30c-5p inhibitors on miR-30c-5p levels in HOMECs. (B) Detection of the effect of exosomal miR-30c-5p on the cell proliferation by the CCK-8 assay. (C) Detection of the effect of exosomal miR-30c-5p on the cell migration by the wound healing assay. (D) Detection of the effect of exosomal miR-30c-5p on the cell tube formation capacity by the tube formation assay. (E) Western blotting analyses of the effect of exosomal miR-30c-5p on SOCS3/STAT3/VEGFA pathway expression in HOMECs. Data are presented as mean ± SD for three independent experiments. *P<0.05, ** P<0.01, ***P<0.001.