Research Paper
Adipocyte-derived exosomal miR-30c-5p promotes ovarian angiogenesis in polycystic ovary syndrome via the SOCS3/STAT3/VEGFA pathway
Figure 3. miR-30c-5p is delivered by adipocyte-derived exosomes and promotes proliferation, migration, and tube formation in HOMECs. (A) Coculture of HOMECs and adipocytes treated with or without GW4869. (B) qRT-PCR detection of miR-30c-5p levels in HOMECs in the coculture system. (C) qRT-PCR detection of miR-30c-5p levels after cell transfection. (D) Detection of the effect of miR-30c-5p on the cell proliferation by the CCK-8 assay. (E, F) Detection of the effect of miR-30c-5p on the cell migration by the transwell assay. (G, H) Detection of the effect of miR-30c-5p on the cell tube formation capacity by the tube formation assay. Data are presented as mean ± SD for three independent experiments. *P<0.05, **P<0.01, ***P<0.001.