Research Paper Volume 14, Issue 22 pp 9264—9279

Figure 1. Increased CD229 expression is correlated with poor survival in MM. (A) CD229 mRNA levels were significantly elevated in MM patients. The signal level of CD229 was shown on the y-axis. Patients were designated as healthy donors with normal bone marrow plasma cells (NP, n = 22), monoclonal gammopathy of undetermined significance (MGUS, n = 44), or multiple myeloma (MM, n = 351), sorted on the x-axis. (B, C) Box plot showed CD229 expression in high-risk versus low-risk MM subgroup (B), and in 8 MM risk subgroups from TT2 patient cohort (C). (D–F) Elevated CD229 mRNA expression was associated with poor overall survival (OS) in MM patients from GSE136337 (D), TT2 (E) and APEX (F) patient cohorts.