Research Paper Volume 14, Issue 21 pp 8661—8687
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
Figure 5. Krill oil rewires gene expression to promote neuron survival. (A) Heatmap from WGCNA analysis shows the correlation values between all of the found modules (gene groups) and defined parameters (krill oil treated, DA neuron survival, OCR and locomotion). The correlation ranges from +1 (completely positively correlated) to -1 (perfect negative correlation). (B–E) Gprofiler plots with functionally enriched transcription factors indicated; (B) Representation of the modules (turquoise, white and saddlebrown) upregulated in day 1 PD animals. (C) Representation of the modules (red, pink and dark grey) downregulated in day 1 PD animals. (D) Representation of the modules (blue, tan, cyan, light cyan, violet, dark magenta, sienna) upregulated in day 3 PD animals. (E) Representation of the modules (magenta, purple, dark olive green, and yellow green) upregulated in day 6 PD animals.