Research Paper Volume 14, Issue 21 pp 8661—8687

Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging

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Figure 1. Krill oil promotes healthy dopaminergic neuronal aging. (A) Representative images of the head region of PD animals at day 1, day 3 and day 6 of adulthood, Scale bar, 20 μm. (B) Survival of anterior CEPs and ADEs DA neurons during aging in response to Krill oil (n = 35 nematodes per experiment; three independent experiments, s.e.m; ***p < 0.001; one-way ANOVA followed by Bonferroni’s multiple comparison test. (C) Representative images of α-SYN aggregation in body wall muscles in day 1 and day 6 animals, Scale bar, 20 μm. (D) The number of aggregates in day 1 and day 6 animals in response to krill oil (n = 15 nematodes, s.e.m; NS and ***p < 0.001; one-way ANOVA followed by Bonferroni’s multiple comparison test). (E) Column scatter plot representing basal slowing response of wild type and PD animals at adult day 6. Body bends per 20 second measured on NGM plates with and without bacteria (n = 30; Error bars, s.e.m; ***p < 0.001; one-way ANOVA followed by Bonferroni’s multiple comparison test. (F) Column scatter plot representing locomotion activity wild type and PD animals at adult day 6. The activity was scored for 60 minutes (n = 50 animals per experiment; Error bars, s.e.m; NS and *p < 0.05; one-way ANOVA followed by Bonferroni’s multiple comparison test.