Research Paper Volume 14, Issue 21 pp 8783—8804
Multilevel data integration and molecular docking approach to systematically elucidate the underlying pharmacological mechanisms of Er-Zhi-Wan against hepatocellular carcinoma
Figure 9. Correlation analysis of the expression of four key cellular senescence-related genes with the clinical characteristics of LIHC patients. (A) The differential expression of CDK1, CDK4, CHEK1, and G6PD between normal and tumor tissues. (B, C) CDK1, CDK4, CHEK1, and G6PD mRNA expression in normal individuals or in patients with different T stages (T1&T2 and T3&T4) and pathologic stages (stage I&II and stage III&IV). (D, E) Differences in the expression of CDK1, CDK4, CHEK1, and G6PD mRNA according to vascular invasion and tumor status. (F) Analysis of the AUCs of the 4 cellular senescence-related genes in LIHC. (G) Kaplan-Meier curves of OS for different cell cycle-related genes. *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001, respectively.