Research Paper Volume 14, Issue 19 pp 8077—8094
Novel small molecular compound 2JY-OBZ4 alleviates AD pathology in cell models via regulating multiple targets
Figure 1. Novel small molecular compound 2JY-OBZ4 is a structural analogue of anti-AD drug, Huperzine A. (A) Chemical structure of 2JY-OBZ4 and Huperzine A (Hup-A). (B) Scatter plot to compare relevant brain penetration characteristics of 2JY-OBZ4 to a set of well-known CNS and peripheral drugs processed by ACD/Percepta. Log(PS*fu, brain) means brain/plasma equilibration rate; LogBB means extent of brain penetration.