Figure 8.Model for rejuvenated effect of lotus germ extract (Neferine) in aging fibroblast. Aging fibroblasts downregulates mitochondria function and collagen production, and upregulates AGEs production and SA-β-gal activity. Lotus germ extract (Neferine) treatment rejuvenated aging fibroblasts by restoring the various phenotypes of aging via activation of DAPK1-Beclin1 signaling induced autophagy.
