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Online ISSN: 1945-4589
Research Paper
|
Volume 14, Issue 18
|
pp. 7527–7546
Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells
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Figure 7
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Figure 7.
Model summarizing the role of FAT10 in renal fibrosis response to UUO injury.
Upon UUO injury, FAT10 up-regulation stabilizes USP7 expression, thereby leading to CHK1-mediated G2/M arrest in RTECs, which further drives fibrogenic responses.
