Research Paper Volume 14, Issue 18 pp 7300—7327

Figure 2. Impaired spatial working memory of SAMP8 mice in Y maze (A) 3 months old mice (B) 6 months old mice (C) 9 months old mice. Mice spent 5 minutes in the entry and open arm, then 5 minutes in free access to new, open and entry arms. Data are mean ± SEM, analyzed by 2-way ANOVA, repeated measures, with Bonferroni post test. Significance is **P < 0.01 and ***P < 0.001. * SAMP8 compared to SAMR1 mice, and ^† open and entry arm compared to the new arm. n = 12 (3 months old), 10 (6 months old) or 5 (9 months old) mice per group.