Research Paper Volume 14, Issue 18 pp 7300—7327

Figure 1. Increased activity measured by open field (A–E) and decreased anxiety measured by elevated plus maze (F, G) of SAMP8 mice. Mice spent 10 minutes in open field where the: (A) total distance (B) covered area (C) wall distance were measured. The representative tracks of 6 months old (D) SAMR1 mice (E) SAMP8 mice. Mice spent 10 minutes in elevated plus maze: (F) 6 months old mice (G) 9 months old mice. Data are mean ± SEM, analyzed by 2-way ANOVA, repeated measures, with Bonferroni post test. Significance is *P < 0.05, **P < 0.01 and ***P < 0.001. *SAMP8 mice compared to SAMR1, + age-dependent changes in SAMR1, # age-dependent changes in SAMP8, and ^† compared closed arm to open arm. n = 12 (3 months old), 10 (6 months old) or 5 (9 months old) mice per group.