Realgar (As4S4), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro

Zonghong Li; Ruiming Zhang; Xuewei Yin; Nana Li; Siyuan Cui; Teng Wang; Xing Tan; Mingyue Shen; Yun Guo; Jinxin Wang; Dadong Guo; Ruirong Xu

doi:doi:10.18632/aging.204281

← Back

Research Paper Volume 14, Issue 17 pp 7109—7125

Realgar (As₄S₄), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro

Figure 6. Measurement of the gene expression of Bcl-2, Bax, Cyt-C and AIF. NB4 cells were treated with different concentrations of realgar (0, 12.5, 25.0, 50.0 and 75.0 μg/ml) for 24, 48 and 72 h, and the mRNA expression levels of Bcl-2, Bax, Cyt-C and AIF were compared to those in untreated cells. (A) Bcl-2 mRNA level; (B) Bax mRNA level; (C) Cyt-C mRNA level and (D) AIF mRNA level. The results are expressed as the mean ± S.D. (standard deviation) of three independent experiments. ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001.