Realgar (As4S4), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro

Zonghong Li; Ruiming Zhang; Xuewei Yin; Nana Li; Siyuan Cui; Teng Wang; Xing Tan; Mingyue Shen; Yun Guo; Jinxin Wang; Dadong Guo; Ruirong Xu

doi:doi:10.18632/aging.204281

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Research Paper Volume 14, Issue 17 pp 7109—7125

Realgar (As₄S₄), a traditional Chinese medicine, induces acute promyelocytic leukemia cell death via the Bcl-2/Bax/Cyt-C/AIF signaling pathway in vitro

Figure 4. Effect of realgar on APL cell cycle arrest. (A) (a) Control, (b) 12.5 μg/mL, (c) 25.0 μg/mL, (d) 50.0 μg/mL, and (e) 75.0 μg/ml. The statistical data were generated by flow cytometry software and plotted as generated. (B) Histogram analysis of cell cycle phase distributions of NB4 cells after treatments with 0, 12.5, 25.0, 50.0 and 75.0 μg/mL of realgar. Data were obtained from three independent experiments and are presented as the mean ± SD. ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001.