Research Paper Volume 14, Issue 17 pp 7093—7108
Tyrosine kinase receptor RON activates MAPK/RSK/CREB signal pathway to enhance CXCR4 expression and promote cell migration and invasion in bladder cancer
Figure 6. Down-regulation of RON inhibits tumorigenesis in vivo and reduces CXCR4 expression in vivo. Representative images of xenograft tumor formation were shown in the LV–shRON group and LV–shNC group in nude mice. RON knockdown reduced the tumor volume and tumour weight in nude mice. The tumor volume growth curve was significantly inhibited in the LV–shRON group (A), and the average tumor weights were markedly lower, as compared with those in the LV–shNC group (B), Furthermore, the CXCR4, E-cadherin and Vimentin proteins expression was significantly decreased or increased compared with controls (C). All data are shown as means ± SEM, **P < 0.01 versus scramble.