Research Paper Volume 14, Issue 17 pp 7093—7108
Tyrosine kinase receptor RON activates MAPK/RSK/CREB signal pathway to enhance CXCR4 expression and promote cell migration and invasion in bladder cancer
Figure 1. High expression of CXCR4 is correlated with RON in BC. Representative immunohistochemical staining for RON (A), and CXCR4 (B) protein expression in BC tumor and adjacent normal tissues. Average scores for RON (C), and CXCR4 (D) in BC tumor versus in adjacent normal tissues. The association with RON and CXCR4 expression in BC clinical samples was analyzed (E). RON and CXCR4 expression were detected by western blot in five representative BC tumor and corresponding adjacent non-tumor tissues (F), as well as in seven urothelial BC cells (G).