Research Paper Volume 14, Issue 16 pp 6481—6506

Figure 4. bmm overexpression increases mitochondrial biogenesis and oxidative metabolism. (A) Heatmap of 63 significantly differentiated metabolites identified between da-GAL4/+ and da-GAL4>UAS-bmm female flies by targeted metabolomics analysis. (B) Heatmap of 32 significantly differentiated metabolites identified between da-GAL4/+ and da-GAL4>UAS-bmm male flies by targeted metabolomics analysis. (C, D) Pathway analysis of significantly differentiated metabolites identified between da-GAL4/+ and da-GAL4>UAS-bmm flies. Each row represents a pathway and each bar indicates the enrichment of the metabolites detected in a given pathway. Color bar represents significance. See also Supplementary Figure 5.