Research Paper Volume 14, Issue 16 pp 6689—6715
Prognostic alternative splicing events related splicing factors define the tumor microenvironment and pharmacogenomic landscape in lung adenocarcinoma
Figure 2. Alternative splicing (AS) events in cancer. (A) Mechanism of splicing regulatory factors in regulating RNA alternative splicing and tumor progression. ES (Exon skip) means that an exon is cut from the original transcript. RI (Retained intron): A new exon is formed by the retained Intron and the exons on both sides. AD (Alternate Donor site): The 3'-end splicing sites of different transcripts are the same but the 5'-end splicing sites are different. AA (Alternate acceptor site): The 5'-end splicing sites of different transcripts are the same but the 3'-end splicing sites are different. AP (Alternate promoter): The first exon of the two transcripts is different. AT (Alternate terminator): The last exon of the two transcripts is different. ME (Mutually exclusive exons): Different exons (called inclusive exons) are present in different transcripts. (B) Upset plot of all AS events in LUAD. (C) Upset plot of prognosis-related AS events in LUAD.