Research Paper Volume 14, Issue 16 pp 6594—6604

MiR-375 mitigates retinal angiogenesis by depressing the JAK2/STAT3 pathway

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Figure 1. Expression of miR-375 is decreased in the retina of OIR. (A, B) A heat map (A) of the significantly differentially expressed microRNAs and the volcano plots (B) between groups. (C) A heat map of the differentially expressed microRNAs, which were consistent with our results, in the retina of OIR from GSE84303. (D, E) miR-375 was significantly downregulated in the retina of OIR group compared with that of the control group both in our samples (D) and in GSE84303 (E). (F) Expression of miR-375 was down-regulated in the retina of CNV. *P < 0.05.