Research Paper Volume 14, Issue 15 pp 6255—6268

Figure 6. Clinical significance of cMAP4K2-mediated signaling in DR. (A and B) qRT-PCR assays were performed to detect the vitreous levels of cMAP4K2 and miR-377 in the patients with DR (n = 30 eyes) or non-diabetic patients with macular hole (non-DR, n = 30 eyes). (C) Receiver operating characteristic (ROC) curve analysis of cMAP4K2 and the corresponding area under curve (AUC) value in the discriminative power of cMAP4K2 for DR. ^*P < 0.05 vs. non-DR group. The significant difference was analyzed by Student t test. (D and E) qRT-PCR assays were performed to detect the levels of cMAP4K2 and miR-377 in the aqueous humor of the patients with DR (n = 30 eyes) or cataract (n = 30 eyes). ^*P < 0.05 vs. cataract group. The significant difference was evaluated by Student t test.