Research Paper Volume 14, Issue 15 pp 6149—6168
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway
Figure 3. IL-17D promotes infiltration of tumor-associated macrophages (TAMs). (A) Representative flow cytometry profiles and percentages of TAMs in CD45+ TILs in subcutaneous tumors (n = 3). Mean ± SD. **P < 0.01. (B) Representative flow cytometry profiles and percentages of CD206+ cells in CD11b+ F4/80+ cell populations in subcutaneous tumors (n = 2). Mean ± SD. *P < 0.05. (C and D) Flow cytometric analysis and quantification of M-MDSCs (C) and G-MDSCs (D) in CD45+ TILs in subcutaneous tumors (n = 3). Mean ± SD. (E, F) Flow cytometric analysis and quantification of CD8+ T cells (E) and CD4+ T cells (F) in CD45+ TILs in subcutaneous tumors (n = 3). Mean ± SD. *P < 0.05. **P < 0.01. (G) Flow cytometric analysis and quantification of NK cells in CD45+ TILs in subcutaneous tumors (n = 3). Mean ± SD. (H) Images of subcutaneous tumors. (I) Subcutaneous tumor size was measured and compared. **P < 0.01. (J) Representative flow cytometry profiles and percentages of TAMs in CD45+ TILs in subcutaneous tumors (n = 2). Mean ± SD. *P < 0.05.