Research Paper Volume 14, Issue 15 pp 6066—6080
PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling
Figure 6. PDCD10 silencing impairs the tumorigenesis and reduces CXCR2 expression of PA cells in vivo. (A, B) Images for Att-20 and TtT/GF xenografts from nude mice (Left). Statistical analysis of xenograft tumor weights (Right). (C, D) Representative IHC images of Att-20 and TtT/GF xenograft tumor tissues for PDCD10, CXCR2 and Ki-67 staining (200x). Scale bars: 100μm. (E, F) Intensity of PDCD10, CXCR2 and Ki-67 staining were analyzed by IHC-Profiler. (G, H) Western blotting was performed to examine the expression of CXCR2 in Att-20 and TtT/GF xenograft tumor samples. Band intensities were quantified and normalized to GAPDH. * P < 0.05.