Research Paper Volume 14, Issue 15 pp 6066—6080
PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling
Figure 1. Expression of PDCD10 in human pituitary adenomas. (A) A dataset (GSE26966) was obtained from the GEO database to compare the mRNA expression level of PDCD10 between PA tumor tissues (N=14) and normal pituitary tissue (N=9). (B) Relative mRNA expression levels of PDCD10 by RT-qPCR in invasive (n=15) and non-invasive (n=15) pituitary adenomas. Non-invasive values were set to 1. (C) Representative Western blots showed the expression level of PCDC10 protein (25 kDa) in invasive and noninvasive pituitary adenomas. Band intensities were quantified and normalized to GAPDH. (D) Representative images of immunohistochemistry evaluated the expression of PDCD10 in invasive and non-invasive (n=15) pituitary adenomas. **P < 0.01; ***P < 0.001; ****P < 0.0001.