microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Qiangfeng Yu; Zhe Xiu; Yizeng Jian; Jianyin Zhou; Xiaopeng Chen; Xiang Chen; Chunxiang Chen; Hongbao Chen; Sijia Yang; Libo Yin; Wenlong Zeng

doi:doi:10.18632/aging.204193

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Research Paper Volume 14, Issue 14 pp 5908—5924

microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Figure 9. miR-497 inhibited the expression of the viability, migration, and invasion biomarker genes. qRT-PCR assay analysis of Ki67, CD147, MMP-2 expression level in CSCs and non-CSCs isolated from populations of AsPC-1 and BxPC-3 cells. ***P< 0.001, compared to the Vector group; ###P< 0.001, compared to the Vector+gemcitabine group. ∆∆P<0.01, Vector+gemcitabine group. Data are shown as mean ± SEM. All experiments were repeated at least three independent experiments.