microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Qiangfeng Yu; Zhe Xiu; Yizeng Jian; Jianyin Zhou; Xiaopeng Chen; Xiang Chen; Chunxiang Chen; Hongbao Chen; Sijia Yang; Libo Yin; Wenlong Zeng

doi:doi:10.18632/aging.204193

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Research Paper Volume 14, Issue 14 pp 5908—5924

microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Figure 10. CSCs promotes tumor growth in vivo than in non-CSCs. A mouse model of Pancreatic cancer was established by subcutaneously inoculating CSCs and non-CSCs. (A) xenograft tumors of each group were shown; (B) Tumor volume was measured every week. (C) The mRNA level of miR-497/ NFkB1 /Ki67/ CD147/MMP-2 in tumors. **p < 0.01, compared to non-CSCs.