Figure 1. Bone health depends on diurnal variation in bone turnover, which is regulated by the circadian timing system. (A) With aging circadian rhythmicity is disturbed, which may contribute to osteoporosis (B). SCN= Suprachiasmatic nucleus, GC= glucocorticoid, HPA axis= hypothalamic-pituitary-adrenal axis. Figure created with BioRender.com