The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Xiaojun Chen; Jiangyan Wang; Lin Tang; Qiuying Ye; Qunwei Dong; Zhangwei Li; Li Hu; Chenghong Ma; Jiake Xu; Ping Sun

doi:doi:10.18632/aging.204172

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Research Paper Volume 14, Issue 14 pp 5727—5748

The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Figure 4. The enrichment results of 77 common genes between FTZ pharmacological target genes and osteoclast-related genes. (A) Top 25 terms of the biological process enrichment. (B) Sankey diagram for the top 25 KEGG enrichment terms, displayed the relationship between enriched genes and pathway terms.