Figure 2. Circulating steroids (ng/mL) among young adult and middle-aged HIV-1 Tat-transgenic male mice [Tat(+)] or their non-Tat-expressing age-matched counterparts [Tat(−)]. (A) Testosterone, (B) estradiol, (C) progesterone, and (D) corticosterone detected in serum. §indicated group differs from young adult Tat(−) controls. ^significant interaction wherein indicated group differs from respective Tat(−) controls. †indicated group differs from all other groups. *main effect for Tat(+) mice to differ from Tat(−) controls, (two-way ANOVA, p < 0.05).