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Research Paper Volume 14, Issue 14 pp 5699—5709

Increased cytochrome C threonine 50 phosphorylation in aging heart as a novel defensive signaling against hypoxia/reoxygenation induced apoptosis

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Figure 1. Aging increases Cytc T50 phosphorylation. Compared with the young, GO annotation revealed that biological function was up-regulated (A) in the old group and down-regulated (B). (C) Relationships between different proteins. (D) Magnified (Figure 1C) portion. (E) T50 expression is different in young and old heart tissue from proteomics. (F) T50 levels in isolated cardiomyocytes (from 8 weeks and 18 months-old mouse hearts) were measured by Western Blot, with specific antibody in Figure 2. n=5 in each group. Data expressed as mean±SD. *** P < .001 vs. young, * P < .05 vs. young.