TRPM7 via calcineurin/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma

Tsung-Ming Chen; Chih-Ming Huang; Ming-Shou Hsieh; Chun-Shu Lin; Wei-Hwa Lee; Chi-Tai Yeh; Shao-Cheng Liu

doi:doi:10.18632/aging.204154

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Research Paper Volume 14, Issue 12 pp 5250—5270

TRPM7 via calcineurin/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma

Figure 6. Pictorial abstract showing the essential role of TRPM7 in the metastasis and chemoresistance of HNSCC cells; silencing TRPM7 suppressed several oncogenic signaling axes, leading to reduced migration, invasion, colony formation, and spheroid formation.