Research Paper Volume 14, Issue 12 pp 5250—5270
TRPM7 via calcineurin/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma
Figure 3. Downregulation of TRPM7 expression inhibits cancer stemness cell proliferation-associated protein in HNSCC. (A) Analysis of the relationship of TRPM7 with NANOG and BMI-1 (B) The possible regulation network of TRPM7. (C) Reduced mRNA expression of TRPM7, c-Myc, BMI-1, and Nanog proteins and TRPM7 knockdown in SAS and FaDu cells based on qPCR analysis. (D) Western blots of tumorspheres derived from HNSCC cells showing the expression profiles of TRPM7, NFATC3, c-Myc, BMI-1, Sox2, and Nanog. *p < 0.05, **p < 0.01.