Research Paper Volume 14, Issue 13 pp 5406—5416
circEPSTI1 promotes tumor progression and cisplatin resistance via upregulating MSH2 in cervical cancer
Figure 1. circEPSTI1 is upregulated in cervical cancer with circRNA features. (A) The contents of circEPSTI1 in ten paired cervical cancer samples and neighboring non-malignant tissues. (B) The relative contents of circEPSTI1 in normal HcerEpic cell line and cervical cancer cell lines. (C, D) Circular transcripts of circEPSTI1 were more stable, in contrast with that of linear EPSTI1 mRNA assessed via actinomycin D treated assay in SiHa and HT-3 cervical cancer cell lines. (E, F) The circular structure of circEPSTI1 was assessed via RNase R assay in SiHa, as well as HT-3 cell lines of cervical cancer. The analyzed gene was selected from the host genes of circEPSTI1 in cervical cancer tissues.