Research Paper Volume 14, Issue 11 pp 4874—4887
Effective natural inhibitors targeting IGF-1R by computational study
Figure 6. Anti- Ewing sarcoma effects of ZINC000014946303 and ZINC000006003042. (A) Cellular viability of Ewing sarcoma cells treated with ZINC000014946303 and ZINC000006003042. (B) Colony formation assay results demonstrate the anti-proliferative effects of ZINC000014946303 and ZINC000006003042 in Ewing sarcoma cells. (C) Numbers of clones formed by Ewing sarcoma cells. (D) Scratch assay results demonstrate that ZINC000014946303 and ZINC000006003042 suppressed the migration of Ewing sarcoma cells. (E) Images from the wound-healing assay representing the migration capacity of Ewing sarcoma cells. Anti- Ewing sarcoma effects of ZINC000014946303 and ZINC000006003042 targeting IGF-1R. (F) Results of western blot; Relative expression of IGF-1R(%Control).