Research Paper Volume 14, Issue 19 pp 7774—7793
DNA methylation-regulated YTHDF2 correlates with cell migration and immune cell infiltration in glioma
Figure 12. Depletion of YTHDF2 inhibits GBM cell proliferation and migration. (A) The expression of YTHDF2 in normal human astrocytes cells (NHA) and GBM cell lines (U87, A172, and U251). (B) The YTHDF2 knockdown efficiency in U251 was verified by qRT-PCR assay. (C) YTHDF2 knockdown significantly inhibited U251 cell proliferation examined by growth curve assay. (D) YTHDF2 knockdown significantly inhibited U251 cell migration examined by transwell assay. (E) YTHDF2 knockdown significantly inhibited U251 cell migration examined by wound healing assay. (F) Pearson correlation analysis the correlation between YTHDF2 and MKI67, VIM expression in TCGA LGG.