Research Paper Volume 14, Issue 10 pp 4556—4571

Figure 2. The validated results of ALDH7A1 expression. The Cancer Genome Atlas (TCGA) database (https://www.cbioportal.org/) was used to validate our results. (A, B) In TCGA database, ALDH7A1 expression levels were lower in tumor tissues than those in normal and adjacent normal tissues (P < 0.001, and < 0.001, respectively). ALDH7A1 expression levels were also lower for patients with nodal metastasis than those without nodal metastasis (P < 0.0257) (C). If the patients were divided into ALDH7A1 -high and –low groups, the high-ALDH7A1 group tended to have better clinical outcomes than the low-ALDH7A1 group did (5-year progression-free survival, 58.7% vs. 48.0%, P = 0.048; 5-year overall survival, 49.0% vs. 47.4%, P = 0.412) (D and E).