Figure 4. PPI network construction and univariate COX regression analysis. (A) PPI network was constructed with interaction confidence value >0.95; (B) The top 10 DEGs which shared the leading nodes in PPI network; (C) Univariate COX regression analysis of 223 DEGs. p<0.05 was considered to be statistically significant; (D) Venn plot displayed the DEGs which shared the top 10 leading nodes in PPI network and were significant related with patients’ survival. p<0.05 was considered to be statistically significant.