Research Paper Volume 14, Issue 10 pp 4402—4424

Figure 5. Hallmark gene sets enriched in the high angiogenesis score group. (A, B) Immune response related gene sets, including IL2-STAT5 signaling, interferon (IFN)-α and IFN-γ response, were enriched in the high-score gliomas in the TCGA (A) and CGGA (B) datasets. (C, D) Hypoxia, IL6-JAK-STAT3 signaling, inflammatory response, TGF-β signaling, and TNF-α signaling via NFkB gene sets were enriched in the high-score gliomas in the TCGA (C) and CGGA (D) datasets. (E, F) Epithelial mesenchymal transition (EMT) and NOTCH signaling gene sets were highly associated with high angiogenesis score in the TCGA (E) and CGGA (F) cohorts.