Research Paper Volume 14, Issue 10 pp 4390—4401
Exercise intervention prevents early aged hypertension-caused cardiac dysfunction through inhibition of cardiac fibrosis
Figure 5. Hypothesized diagram. Schematic diagram from the present study showing that early aged hypertension activate the cardiac fibrotic upstream pathway (LOX-2, TGF-β, CTGF and p-Smad2/3), and activate the cardiac fibrotic downstream pathway (MMP2/TIMP2, MMP9/TIMP1, uPA and Collagen I) in the early aged hypertension. However, exercise training through the attenuated angiotensin II type I receptor and FGF23 and suppress cardiac LOXL2/ TGF-β-mediated fibrotic pathways on the early aged hypertensive heart.