Research Paper Volume 14, Issue 10 pp 4247—4269

Figure 3. Effect of Humanin G (HNG) on TNF-α, MIP-1α, and IFN-γ proteins. TNF-α protein was elevated in AMD plasma (A) and in AMD RPE cybrid cells (B) compared to their normal counterparts. Treatment with HNG reduced TNF-α protein levels in AMD RPE cybrid ells (C) but not in normal RPE cybrid cells (D), compared to their untreated counterparts. MIP-1α protein was elevated in AMD plasma (E) and in AMD RPE cybrid cells (F) compared to their normal counterparts. Treatment with HNG reduced MIP-1α protein levels in AMD RPE cybrid ells (G) but not in normal RPE cybrid cells (H), compared to their untreated counterparts. IFN-γ protein was elevated in AMD plasma (I) and in AMD RPE cybrid cells (J) compared to their normal counterparts. Treatment with HNG reduced IFN-γ protein levels in AMD RPE cybrid cells (K) but not in normal RPE cybrid cells (L), compared to their untreated counterparts. Data are presented as mean ± SEM. * P<0.05; ns: non-significant.