Figure 6 — Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

Priority Research Paper|Volume 14, Issue 10|pp. 4195–4210

Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

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Figure 6.Higher doses of CQ attenuated proteasome activity in the liver and heart. Treatment with increasing doses of chloroquine significantly reduced proteasome activity in the liver at a dose of 100 mg/kg (A), whereas proteasomal activity in the heart was reduced only at 200 mg/kg (B). Data are given as arbitrary fluorescence units per mg protein as indicated in the materials and method section of the manuscript. N = 5 for each group.