Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties
Figure 15.Effects of presence of WT-TP53 on glycolysis. Glycolysis for STAT, glycolytic capacity, and glycolytic reserve for STAT were measured by the Seahorse instrument. The data for MIA-PaCa-2 + pLXSN is the same control as presented in . Both MIA-PaCa-2 + MIA-PaCa-2 + WT-TP53 were examined the same time on the Seahorse machine. STAT is an abbreviation for statistics used in study which was the Mann–Whitney test.